CHUM is the 6th largest French public hospital, affiliated with the University of Montpellier.
The Department of Endocrinology, Diabetes and Nutrition (DEDN) is involved in the development and assessment of innovative technologies dedicated to diabetes care, including portable and implantable insulin pumps, continuous glucose monitoring (CGM) systems, artificial pancreas (AP) models, as well as pancreas and islet transplantations. It holds a specific unit for education and follow-up of patients using technologies for diabetes care.
The DEDN at CHUM includes 56 beds dedicated to patient care specialized in diabetes, endocrine and metabolic diseases. Clinical care activity in 2017 included 12000 cumulated days for hospitalized patients and 10000 outpatient visits.
The DEDN is affiliated to the Medical School of the University of Montpellier. Its teaching and research staff comprises 3 full professors and 2 chief residents. Seven medical practitioners, 1 surgeon specialist in implantation of artificial devices and 1 medical research practitioner (Dr Anne Farret), 1 post-doctoral fellow, 1 research engineer (Jerome Place) and 1 research assistant are also included in the permanent staff dedicated to diabetes technology. Seven residents/fellows are currently hosted in DEDN. Its research activities are developed in the UMR CNRS 9203/INSERM U1191 Research Institute at the University of Montpellier. The two leading research domains include the clinical assessment of innovative insulin delivery systems connected to glucose sensing devices for the development of artificial pancreas models, and the performance of islet transplantation in patients with type 1 diabetes. The Department is currently coordinated by Professor Eric Renard, MD, PhD, who also coordinates the Clinical Investigation Centre INSERM 1411 at CHUM.
The DEDN shares a long-term partnership with the Department of Gut Surgery both for patient care activities (bariatric surgery) and clinical research activities in diabetes, metabolic surgery and pancreas transplantation (Professor Fabrizio Panaro). This research partnership allows an access to the Investigational Surgery facility at Montpellier Medical School for experiments in animals.
PI
Prof. Eric Renard, MD, PhD (male), holds a Chair of Professor of Endocrinology, Diabetes & Metabolism at Montpellier Medical School, University of Montpellier, since 1999, and the Head of the Department of Endocrinology, Diabetes and Nutrition, at Lapeyronie University Hospital, Montpellier, since 2010. Eric Renard was also Medical Director of Clinical Research at Montpellier University Hospital (2008-18) and is Head of the INSERM 1411 Clinical Research Centre at Montpellier University Hospital since January 2010.
He leads a research team focusing on ‘Determinants and correction of the loss of insulin secretion in diabetes’ at the Institute of Functional Genomics, UMR CNRS 5203/INSERM U1191/ University of Montpellier, Montpellier, since 2012. Professor Renard devoted his work on developing insulin pump therapy, intra-peritoneal insulin delivery and closed-loop insulin delivery systems and authored more than 250 peer-reviewed papers.
Dr. Anne Farret, MD, PhD (female), holds a position of Senior Clinical Research investigator at Montpellier University Hospital in the Department of Endocrinology, Diabetes and Nutrition. She has a broad expertise in the evaluation of medical devices dedicated to diabetes monitoring, therapy and control, including insulin pumps, CGM systems and artificial pancreas in outpatients.
Pr. Fabrizio Panaro, MD, PhD (Male), is surgeon of the Montpellier Medical Center, Department of Surgery in the College of Medicine at Montpellier, and as a Professor of Surgery for the Montpellier University. Professor Panaro’s main fields of activity and research are surgery of the liver, biliary tract and pancreas, and liver/pancreas transplantation.
He is permanent Visiting Professor of Surgery at the University of Illinois at Chicago (UIC). He is particularly involved in the treatment of hepatocellular carcinoma and of liver metastases. Highly interested in new technologies, the miniinvasive and robotic surgery. He has delivered more than 200 lectures on his research interests around
the world, and has more than 120 publications in peer-reviewed journals. He is member-at-large of International Hepato-Pancreato-Biliary Association (IHPBA) and of the International Pancreas Ilets Transplant Association (IPITA). He currently serves on the editorial board for a number of prestigious journals. Fabrizio Panaro holds a specific expertise in investigational surgery that he performs at the
facility for research in animals of Montpellier Medical School.
Jérôme Place, MSc (male), is a senior research engineer at the Institute of Functional Genomics, UMR CNRS 5203/INSERM U1191/ University of Montpellier, Montpellier, working in the team led by Prof. Renard. He is coordinator of many clinical studies dedicated to diabetes technology and has developed remote monitoring systems used for the investigation of outpatients testing artificial pancreas systems.
He is also data manager of multicenter clinical studies of insulin delivery and CGM systems and holds ability of statistical analyses.
CHUM will be involved in:
WP1: Hormone refilling strategy
WP3: Intra-peritonal Model Predictive Control (MPC) and Novel intra-peritoneal T1D simulator
WP4 (leader): Implantation surgical procedures and preclinical BIP validation
WP6: Clinical validation of ip control algorithm (based on sc glucose sensing & DiaPort), First-in-human testing of BIP components, First-in-human investigations.
WP7: Exploitation/innovation and dissemination
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